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5-LOX Inhibitor with AprèsFlex 100 mg 60 vegetarian capsules

7-Keto DHEA Metabolite 100 mg, 60 vegetarian capsules

7-Keto DHEA 100 mg 120 Vcaps

7-Keto DHEA 100 mg 60 vcaps

Acetyl-L-Carnitine 500 mg 100 vegetarian capsules

Acetyl-L-Carnitine Arginate 100 vegetarian capsules 100 vegetar

Adrenal Energy Formula 120 vegetarian capsules

Adrenal Energy Formula 60 vegetarian capsules

Advanced Anti-Adipocyte Formula 60 vegetarian capsules

Advanced Lipid Control 60 vegetarian capsules

Advanced Natural Appetite Suppress 60 vegetarian capsules

Advanced Olive Leaf Vascular Support with Celery Seed Extract 60

Advanced Oral Hygiene 60 mint lozenges

Algae Omega 60 gels

AMPK Metabolic Activator

Anti-Aging Rejuvenating Scalp Serum 2 oz (60 ml

Anti-Aging Rejuvenating Scalp Serum 2 oz (60 ml)

AppleWise Polyphenol Extract 600 mg 30 vegetarian capsules

Arginine Caps 700 mg 200 vegetarian capsules

Arginine Ornithine Powder 150 grams (5.29 oz)

Arterial Protect 30 vegetarian capsules

Arthromax™ Advanced with UC-II® & AprèsFlex® 60 capsules

ArthroMax® Herbal Joint Formula

Arthroplex 190 caps Thorne Research

Ashwagandha Extract Oimized t (Stimulant Free)

Asian Energy Boost 90 vegetarian capsules

Astaxanthin BioAstin Astaxanthin 12mg 50 Gelcap

Astaxanthin with Phospholipids 4 mg 30 softgels

Athletic Nutrients 180 Capsules Pure Encapsulations

Bacopa -- 60 Vegetarian Capsules

Bacopa 60 Vegetarian Capsules

BCAA Powder 227 Grams Pure Encapsulations

Benfotiamine (Mega) 250 mg, 120 vegetarian capsules)

Benfotiamine With Thiamine 100 mg, 120 vegetarian capsules

Berberine 500 mg 60 caps

Berry Complete Enhanced Berry Complete with Açaí

Beta Glucan & Aloe Skin Renewal Anti-Aging Cream 2 oz With WGP®

Beta Glucan 500 mg 100 caps

BetterWOMAN® 40 capsules

Bifido GI Balance

BioSil Skin, Hair, Nails 120 vcaps

Biosil Skin, Hair, Nails 30 vcaps

BioSil Skin, Hair, Nails 60 vcaps

BioSil Beauty, Bones, Joints 1 fl oz

Biotin 600 mcg, 100 capsules

Black Cumin Seed Oil 60 softgels

Black Cumin Seed Oil with Bio-Curcumin® 60 softgels

Black Seed, Cold-Pressed Oil, 8 fl oz Amazing Herbs

Blood PressureTriple Action Blood Pressure 60 vegetarian tablet

Blood Presure Natural BP Management 60 tablets

Blueberry Extract with Pomegranate 60 vegetarian capsules

Bluebonnet Calcium Magnesium Potassium 90 caplets

Bone Restore 120 capsules

Bone Restore with Vitamin K2 150 Capsules

Bone Strength Formula with KoAct® 120 capsules

Booster Once-Daily Health Booster 60 softgels

Boron 3 mg, 100 vegetarian capsules

Brain Shield 60 vegetarian capsules

Branched Chain Amino Acids (Free Form) 90 capsules

Brassica Green Tea with SGS

Brite Eyes III

Broccoli Sprout Cream

Buffered Vitamin C Powder 454 grams (16 oz)

CalApatite Bone Builder Forte 180 caps

Calcium & Magnesium 120 tablets

California Estate Organic Extra Virgin Olive

CalReduce Selective Fat Binder

Canine Basic Nutrients 120 Capsules

Canine Geriatric Basics 120 caps Thorne Research

Canine Geriatric Basics 120 Capsules

Cardio Peak™ with Standardized Hawthorn and Arjuna 120 ve

Carnitine Optimized Carnitine with GlycoCarn® 60 vegetarian

Carnosine Super Carnosine 500 mg 60 vegetarian capsules

CDP-Choline Caps 250 mg 60 vegetarian capsules

CHOL-Support 60 liquid vegetarian capsules

Cholestene 120 Capsules

CinSulin® with InSea2® and Crominex

CLA Blend with Guarana and Sesame Lignans (Super) 1000 mg, 120 s

CLA Super CLA Blend with Sesame Lignans 1000 mg, 120 softgels

CocoaMind 14 single-serving packets

CoffeeGenic® Green Coffee Extract 200 mg 90 Veg Caps

Cognitex with Brain Shield 90 softgels

Cognitex with Pregnenolone & Brain Shield 90 softgels

Collagen Bio-Collagen with Patented UC-II® 40 mg, 60 small cap

Collagen Super Collagen+C

Comprehensive Nutrient Packs ADVANCED 30 packets

CoQ10 SuperUbiquinol CoQ10 with Enhanced Mitochondrial 200mg

CoQ10 Super Ubiquinol CoQ10 with Enhanced Mitochondrial 100mg 6

CoQ10 Super Ubiquinol CoQ10 with BioPQQ 100 mg 30 softgels

Cran-Max Optimized with UTIRose 60 Veg Caps

Cran-Max® Cranberry Whole Fruit Concentrat500 mg, 60 vegetar

Creatine Capsules 120 vegetarian capsules

Curcumin Advanced Bio-Curcuminwith Ginger & Turmerones

Curcumin(Super Bio-Curcumin®) 400 mg, 60 vegetarian capsules

Cytokine Suppress 30 vegetarian capsules

D-Ribose Powder 150 grams

DHA Vegetarian Sourced DHA 30 vegetarian softgels

DHEA (Dehydroepiandrosterone) 100 mg 60 vegetarian capsules

DHEA (Dehydroepiandrosterone) 25 mg 100 dissolve in mouth tablet

DHEA (Dehydroepiandrosterone) 25 mg, 100 capsules

DHEA (Dehydroepiandrosterone) 50 mg 60 capsules

DHEA (Dehydroepiandrosterone)15 mg 100 capsules

DHEA Complete 60 vegetarian capsules

Digestion Enhanced Super Digestive Enzymes With Probiotics

Dim 150 ( 60 Capsules)Bio Response

DMAE Bitartrate 150 mg 200 vegetarian capsules

DNA Protection Formula 60 vegetarian capsules

Dog Mix 100 grams (3.52 oz)

Dopa-Mind 60 vegetarian tablets

Elderberry Instant Immune POW-der

Endothelial Defense with Full-Spectrum Pomegranate and CORDIAR

Enhanced Fernblock® with Red Orange Complex

Enzalase 50 caps

Esophageal Guardian Natural Berry Flavor 60 chewable tablets

European Leg Solution featuring Certified Diosmin 95 600 mg 30 v

Evening Primrose Oil 1300 mg 120 gels

Extraordinary Enzymes 60 Capsules

Eye Pressure Support with Mirtogenol 30 vegetarian capsules

Fiber Garden of Life, RAW Fiber, Beyond Organic Fiber, 1.77 lbs

Fibrinogen Resist

Fish Oil Super Omega-3 EPA/DHA Sesame Lignan Olive Frut 120

Fish Oil Super Omega-3 EPA/DHA Sesame Lignan Olive Frut 240

Fish Oil Enteric coated softgels Super Omega-3 EPA/DHA withSesa

Fish Oil Super Omega with Krill & Astaxanthin 120 softgels

Florasone Cream 1 oz

Florassist Mood 60 capsules

Florassist Balance 30 liquid vegetarian capsules

Florassist Throat Health 30 lozenges

Florassist ® Oral Hygiene30 lozenges

FLORASSIST® GI with Phage Technology

FlorAssist® Heart Health Probiotic 60 vegetarian capsu

Folate High Potency Optimized Folate L-Methylfolate 5

Folate Optimized Folate (L-Methylfolate) 1000 mcg 100 vegetarian

Formula SF722 Thorne Research

Forskolin 10 mg, 60 vegetarian capsules

G.I. Benefits 30 servings Davinci Labs

Garcinia Cambogia,Garcinia HCA 90 vegetarian capsules

Garlic Optimized Garlic 200 vegetarian capsules

Gastro-Ease

Ginkgo Biloba, 120 Veggie Caps Paradise Herbs

Glucosamine/Chondroitin Capsules 100 capsules

Glucosamine/Chondroitin Capsules 100 Capsules

Glutamine L-Glutamine 500 mg 100 capsules

Glutamine L-Glutamine Powder 100 grams (3.52 oz)

Glutathione Powder 50 Grams

Glutathione Powder 50 Grams Special Buy 5 get one bottle free

Glycemic Guard 30 vegetarian capsules

Glycine 1000 mg, 100 capsules

Glycine Powder 1 lb Now

Green Tea Green Tea Extract (Lightly Caffeinated) 100 vegetarian

Green Tea Mega Green Tea Extract (Decaffeinated)100 vegetarian

GreenTea 70

Hair, Skin & Nails Rejuvenation Formula with VERISOL® 90 tablets

HepatoPro (Polyunsaturated Phosphatidylcholine) 900 mg 60 sof

Holy Basil Force 120 softgels

Hyaluronic Acid 180 Capsules Pure Encapsulations

Hydrating Anti-Oxidant Face Mist 4 oz

Iberogast ( Medical Futures Inc)

Immune Protect with Paractin

Immune Senescence Protection Formula™

Innate Detox™ 90 Caps

Inositol Capsules 1000mg 360 capsules

Inositol Powder Net Weight 16 oz

Iodine Sea-Iodine 1000 mcg 60 capsules

Iodoral Vitamin Research 180 tablets

Iron Protein Plus 300 mg 100 capsules

Italian Borlotto variety bean extract Advanced Natural Appetite

Joint Formula Fast-Acting 30 Capsules

Krill Healthy Joint Formula 30 softgels

L--Lysine 620 mg 100 vegetarian Capsules

L-Carnitine 500 mg 30 vegetarian capsules

L-Citrulline 600 mg 100 caps

L-Citrulline Powder 100 gms Nutricology/ Allergy Research

Lecithin 1200 mg 100 gels

Lecithin 97% Phosphatides De-Oiled 454 grams (1 lb or 16 oz)

Liquid Calcium Magnesium Citrate Plus Vitamin D3 (blueberry)

Liquid Glucosamine 1500-Chondroitin-MSM 16oz Dr's Advantage

Liquid Vitamin D3

Lithium 5mg

MacuGuard™ Ocular Support wIth Astaxanthin 60 softgels

Magnesium (Citrate)

Magnesium Caps 500mg 100 Capsules

Magnesium Neuro-Mag™ Magnesium L-Threonate 90 vegetarianca

Magnesium Neuro-Mag® Magnesium L-Threonate Tropical Punch Flavor

Mediterranean Trim with Sinetrol 60 vegetarian capsules

Melatonin 6 Hour Timed Release 3 mg 60 vegetarian tablets

Melatonin 10 mg 60 capsules

Melatonin 3 mg 60 capsules

Melatonin 3 mg 60 vegetarian lozenges

Melatonin 6 Hour Timed Release 750 mcg 60 vegetarian tablets

Melatonin Fast-Acting Liquid Melatonin

Migra-Eeze™Standardized Butterbur-Ginger-Riboflavin Formula

Milk Thisle Certified European Milk Thistle 120 softgels

Milk Thistle Certified European Milk Thistle 60 vegetarian c

Mitochondrial Energy Optimizer with BioPQQ® 120 capsules

MitoQ 5mg Vegicaps

MitoQ® 5mg Vegicaps Triple Pack

MitoQ® Moisturizing Anti-Aging Serum 1.7FL oz (50ml

Monolaurin 600 mg 90 caps Ecological Formulas

Multi Vitamin Children's Chewable120 Chewable Tablet

Multi Vitamins Life Extension One-Per-Day Tablets 60 tablets

Multi Vitamins Life Extension Two-Per-Day Tablets 60 tablets

Multi Vitamins Life Extension Mix Powder without Copper 420gra

Multi Vitamins Life Extension Mix Capsules without Copper 490ca

Multi Vitamins Life Extension Mix Tablets 315 tablets

Multi Vitamins Life Extension Mix Tablets without Copper 315 ta

Multi Vitamins Life Extension Mix™ Capsules 490 capsules

Multi Vitamins Life Extension Mix™ Powder 420 grams (14.81 oz)

Multi Vitamins Two-Per-Day Capsules 120 capsules

Multi Vitamins Two-Per-Day Tablets 120 tablets

Mung Bean Soup with Turmeric

N-Acetyl-L-Cysteine 600 mg, 60 vegetarian capsules

N-Acetyl-L-Cysteine600 mg, 60 vegetarian capsules

NAD+ Cell Regenerator250 mg, 30 vegetarian capsules

NAD+ Cell Regenerator™ Nicotinamide Riboside

Natural Estrogen 60 vegetarian tablets

Natural Sleep Melatonin 5 mg 60 vegetarian capsules

Natural Sleep® 60 vegetarian capsules Melatonin 3 mg

Natural Stress Relief 30 vegetarian capsules

Niacin (No Flush) (Inositol Hexanicotinate) 800 mg 100 capsules

Nordic Naturals Berries 200 Chews

Nordic Naturals Omega-3 Worms 30 worms

Nordic Naturals, Ultimate Omega, Lemon Flavor, 1000 mg, 180 Soft

Nordic Omega-3 Gummies

Optimized Fucoidan with Maritech® 926

Optimized Irvingia with Phase 3 Calorie Complex

OrganoGermanium 100 mg 100 tabs

Pantothenic Acid (Vitamin B5) 500 mg 100 capsules

Phosphatidylserine Lef PS Caps 100mg 100 capsules

Plant Protein Complete & Amino Acid Complex Vanilla Flavor

PMS Support (Chaste Tree Dandelion), 340 mg, 45 Veggie Caps

Policosanol 10 mg 60 tablets

PQQ Caps with BioPQQ 20 mg 30 vegetarian capsules

PQQ Caps with BioPQQ10 mg 30 vegetarian capsules

Pregnenolone 100mg 100 capsules

Pregnenolone 50mg 100 capsules

Prelox Natural Sex for Men® 60 tablets

Probiotic Dr. Ohhira\'s Probiotics 12 Plus, Professional Formul

ProDHA Eye 120 gels

Prostate Ultra Natural Prostate softgels

PROVINAL Omega-7 PROVINAL® Purified Omega-7 30 softgels

Pycnogenol® 100 mg 60 vegetarian capsules

Quercetin Optimized Quercetin 250 mg 60 vegetarian capsules

R-Lipoic Acid Super R-Lipoic Acid 300 mg 60 vegetarian capsules

Reishi Extract Mushroom Complex

RejuveneX® Factor Firming Serum 1.7 oz (50 ml)

Resveratrol Optimized NAD+ Cell Regenerator

Resveratrol Optimized Resveratrol

Resveratrol Optimized Resveratrol with Nicotinamide Riboside

Rhodiola Extract (3% Rosavins)250 mg, 60 vegetarian capsules

RiboGen French Oak Wood Extract 200 mg, 30 vegetarian capsules

SAMe (S-Adenosyl-Methionine) 200 mg 20 enteric coated tablets

SAMe (S-adenosyl-methionine) 400 mg 50 enteric coated tablets

SAMe (S-adenosyl-methionine) 400mg 20 tablets

SAMe (S-adenosyl-methionine)200 mg, 50 tablets

Saw Palmetto 60 gels Standardized

Skin Restoring Phytoceramides with Lipowheat 30 veg liquid caps

Skin Stem Cell Serum 1 oz

Skin Tone Equalizer

Spectra Greens 9.95 Ounces Powder Davinci

SPECTRA PURPLES

SPECTRA REDS

Stem Cell Cream with Alpine Rose 1 oz

Strontium Caps 750 mg, 90 vegetarian capsules

Sun Glasses (OveRxCast Polarized Sunglasses) designed to be worn

Super MiraForte with Standardized Lignans 120 capsules

Super Selenium Complex 200 mcg & Vitamin E 100 vegetarian ca

Tart Cherry Extract 60 vegetarian capsules

Taurine 1000 mg, 50 capsules Life Extension

Taurine L-Taurine Powder 300 grams (10.58 oz.)

Tear Support with MaquiBright & Maqui Berry Extract

Theanine L-Theanine 100 mg 60 vegetarian capsules

Theralac 30 caps

Thyroid Triple Action Thyroid 60 vegetarian capsules

TMG 500 mg, 60 liquid vegetarian capsules

TMG Powder 50 grams (1.76 oz)

Tocotrienols Super-Absorbable Tocotrienols 60 softgels

Tocotrienols with Sesame Lignans 60 softgels

Tooth Paste Life Extension Toothpast

Trace Minerals Only Trace Minerals 90 vegetarian capsules

Tranquil Tract 60 vegetarian capsules

Tri Sugar Shield 60 vegetarian capsules

Triple Action Cruciferous Vegetable Extract 60 vegetarian capsul

Triple Action Cruciferous Vegetable Extract with Resveratrol 60

TruFlora 32 vcaps

Tryptophan L-Tryptophan Optimized Tryptophan Plus

Tryptophan L-Tryptophan 500 mg 90 vegetarian capsules

Turmeric Force, 60 Softgel Capsules New Chapter

Ultra Nutrient 180 Vcaps Pure Encapsulations

Ultra Nutrient 360 Vcaps Pure Encapsulations

Ultra Rejuvenex® 2 oz jar

Under Eye Refining Serum Darkness · Puffiness · Fatigue 0.5 oz

Under Eye Rescue Cream 0.5 oz

Under Eye Serum Advanced Under Eye Serum with Stem Cells 0.33 oz

Uric Acid Control 60 vegetarian capsules

Valerian Extended Release 600 mg 30 tablets

VenoFlow30 vegetarian capsules

Venotone 60 capsules

Vitalica Extra Strength Physicians Formula 60 Capsules

Vitalica Plus, Enzyme Activated Broccoli Supplement, 30 Capsules

Vitamin B BioActive Complete B-Complex 60 vegetarian capsules

Vitamin B-Complex Plus 60

Vitamin B12 (Methylcobalamin) 5mg 60 lozenges

Vitamin B6 Pyridoxal 5'-Phosphate Caps 100 mg 60 veg caps

Vitamin C Effervescent Vitamin C - Magnesium Crystals

Vitamin C Fast-C® with Dihydroquercetin 120 vegetarian tablets

Vitamin C Powder (Buffered) 454.6 grams

Vitamin C with Dihydroquercetin 1000 mg, 250 tablets

Vitamin D Lotion 4 oz

Vitamin D3 (Liquid Emulsion

Vitamin D3 10,000 IU 60 vcaps

Vitamin D3 10,000 with K2 60 Metagenics

Vitamin D3 1000 IU, 250 capsules

Vitamin D3 5000 IU 60 Softgels

Vitamin D3 5000 IU 250 vcaps

Vitamin D3 7,000 IU 60 softgels

Vitamin D3 with Sea-Iodine5,000 IU, 60 capsules

Vitamin E Gamma E Tocopherol with Sesame Lignans

Vitamin E Gamma E Tocopherol/Tocotrienols

Vitamin E Unique E 120 softgels

Vitamin K Low-Dose Vitamin K2 45 mcg 90 softgels

Vitamin K Healing Vitamin K Cream

Vitamin K Super K)With Advanced K2 Complex

Vitamin KLow-Dose Vitamin K2 45 mcg, 90 softgels

Vitamins D and K with Sea-Iodine 60 capsules

Waist-Line Control 120 vegetarian capsules

Water-Soluble Pumpkin Seed Extract 60 vegetarian capsules

Whey Protein Isolate (Natural Chocolate Flavor) 454 grams (1 lb.

Whey Protein Isolate (Natural Vanilla Flavor) 454 grams (1 lb. o

Whey Protein New Zealand Whey Protein Concentrate Natural Chocol

Whey Protein New Zealand Whey Protein Concentrate Natural Vanill

Youth Serum 1 oz

Yummi Bears Organic Multivitamin 90 Gummies Hero

Zinc Caps High Potency 50 mg 90 vegetarian capsules

Zyflamend Prostate 60 gels

Zyflamend® Whole Body 120 softgels


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MitoQ 5mg Vegicaps $59.95

Mitoq 5mg 60 Vegicaps

MITOCHONDRIA-TARGET ANTI-OXIDENT

SUPPORTS ENERGY AND KEY ORGAN HEALTH

60 Clear Vegicaps

Adult dose Serving Size 2 Capsules

Take 2 capsules each morning. Do not exceed dose unless directed by your physician. Consult your physician if you are pregnant or nursing.

Active ingredient: Mitoquinol Mesylate equivalent to 5mg Mitoquinol.

Also contains: Microcyrstalline Cellulose, Tapioca, Silicon Dioxide,

MitoQ contains no animal products or gluten.

MitoQ is a patented antioxidant that targets the mitochondria, our cellular power plant, to support

optimal cell function and heart, liver and brain health. MitoQ also boosts energy, and reduces the cellular free radical damage that, over time, causes us to age and can manifest as disease.Levels of Cellular CoQ (aka CoQ10, ubiquinone or ubiquinol) decline from age 20, so many people supplement with CoQ to assist energy levels, to support certain health conditions, and when taking medicines that deplete CoQ (like statins for heart disease). Unfortunately, most CoQ formulas do not reach the mitochondria at levels that are needed.MitoQ is different. It has been designed to replenish antioxidant levels in the mitochondria and in so doing assists the cell with repair and regular function, and acts as an antioxidant reservoir to reduce the damage that excess free radicals cause to DNA and cell membranes.MitoQ, when taken with a good diet and regular exercise, will support healthy aging

MITOQ, THE FIRST MITOCHONDRIA-TARGETED ANTIOXIDANT FORMULA, SELECTED FOR USA’S NATIONAL
INSTITUTE OF AGING’S INTERVENTIONS TESTING PROGRAM.
18th November 2015

We are excited to announce that MitoQ, the world’s first mitochondrial-targeted antioxidant formula, has
been selected for the USA’s National Institute of Aging’s (NIA) Interventions Testing Programme (ITP) – an
internationally renowned anti- aging testing programme funded by the US Government.

In a recent interview Greg Macpherson, NZ CEO of MitoQ, said “our selection for NIA testing is a huge
step forward for MitoQ. Selection by the globally-recognised ITP programme validates a widening view
within the research community that MitoQ confers anti-aging benefits. We are honoured to be acknowledged
in company with well-known compounds shown to extend age-span and health-span, such as rapamycin
and aspirin, which were also selected for this programme and are now proven to positively impact
longevity and health span.”selected for this important trial comes from MitoQ’s ability to optimise mitochondria
and their activity. When mitochondria are returned to what can be described as ‘youthful activity’,
the benefits to cells, organs and the body are clear. MitoQ has the novel ability to deliver the body’s natural
antioxidant CoQ10 to mitochondria in a way that has never been achieved before. Mitochondria are also
known as our ‘cellular batteries’ and are present in almost every cell in the body. Flooding the mitochondria
with antioxidants has the twin effect of improving the level of energy available to a cell and also reduces
free radical-associated cell damage. Greg Macpherson explains, “mitochondria are intricately linked to the
aging process. If we can improve the way they function and slow free radical leaking, we may slow down the
aging process and keep all of our organs and body healthier and younger for longer.”

The NIA is part of the US National Institute of Health, an organisation that invests over $US30 billion per
annum into health research. It was set up by US Congress in 1974 to “understand the nature of aging and
extend the healthy, active years of life”. In pursuit of this research, a global selection process by two expert
panels of scientists invites a small number of compounds with exceptional potential to reverse or decelerate
the aging process for testing each year.

For MitoQ to be selected it must “show significant potential to delay or decelerate the aging process and
improve general health”. Spokesperson for NIA and Principal Investigator of the ITP Research Programme,
Randy Strong, Professor at the Department of Pharmacology and Barshop Institute for Longevity and Aging
Studies, and University of Texas Health Science Center at San Antonio, affirms,“in my opinion, mitochondrial
targeting of antioxidants has potential to improve several aspects of health. MitoQ was considered by
both selection panels to have good potential to impact healthy aging.”

The compounds selected for the programme are tested over a three to five year period to determine their
impact on aging. The programme is renowned for its life-extending findings. Professor Strong said “our discovery
that rapamycin has such a large effect on lifespan, even when started late in life, has, I believe,
changed the way the research community thinks about aging. My guess is that the proliferation of companies
that are seeking treatments for aging and the reputed $500 million USD investment by Google in the
company CALCICO to find treatments for aging, are consequences of those findings.”

Dr Mike Murphy, co-developer of MitoQ says, ” I'm delighted that MitoQ, the molecule Rob Smith and I
developed in New Zealand over 15 years ago, is now being tested in the US National Institute of Aging -
Intervention Testing Program (NIA-ITP). While many compounds are claimed to affect aging in mammals,
to really assess this requires hugely expensive studies lasting several years. Only a handful of such studies
have been done, mainly by the NIA-ITP. This program only selects a few of the most promising anti-aging
compounds for testing each year so their choosing MitoQ is very gratifying. During the program they will
assesses the effects of MitoQ on a wide range of health markers. From this sort of study in the past the
NIA-ITP has been able to confirm that some compounds (eg rapamycin) do decrease some of the negative
effects of aging and extend lifespan. Just as importantly, the NIA-ITP has also shown that other compounds
that have been widely claimed to affect aging (eg resveratrol) are actually ineffective. We will find out in a
few years' time whether MitoQ does improve healthy aging and slow the onset of aging-associated diseases.
The beauty of the NIA study is that the work is done to such a high standard and is entirely independent
of anyone with an intellectual or commercial interest in MitoQ, that it will be hard to argue
with the final findings”.

Results of the ITP trial will be available in 2020 and will be published in numerous leading mainstream scientific
journals such as Nature, Journals of Gerontology and Aging Cell. When speaking about his work Professor
Strong says “the ITP is designed to be exploratory, get high quality data on a compound’s potential
to impact healthy aging. This spurs the international research community to pick up on positive findings and
do additional studies.”

ABOUT MITOQ
Since MitoQ’s discovery in an Otago University laboratory in 2000, the company has invested heavily in further
research and development to better understand the potential of MitoQ for human health. MitoQ has
significantly increased the global research community’s understanding of mitochondria and their link to human
health and aging. To be recognised by the NIA on the international anti-aging stage attests to the 15
years of hard work and investment by Kiwi scientists, the global research community and the MitoQ team to
positively affect the aging process.

Research has shown that aging and its associated health issues and lower energy levels is linked to a decline
in mitochondrial function. Mitochondrial dysfunction is now known to be associated with over 200 diseases
or conditions. Healthy mitochondria generate the energy our cells need to operate, they are the key to
slowing the aging process and improving our health span over the long term.
More than a decade and $50million USD has been spent researching and developing MitoQ, and as a result
MitoQ Ltd has created a leading-edge health range that targets the body’s mitochondria for healthy living
with anti-aging benefits.

MitoQ’s patented and revolutionary science works by attaching a positive charge to CoQ10 – which is also
the mitochondria’s own natural antioxidant. This small change causes positively-charged MitoQ to literally
flood negatively-charged mitochondria, thus restoring antioxidant capacity to youthful levels. This results in
mitochondria that deliver youthful levels of energy to cells and reduces free radical damage to cell contents
to, in essence, decelerate the aging process.

Until now, no other product has ever been able to penetrate mitochondria to deliver antioxidants to the
body in meaningful levels. Other sources of CoQ10 are unable to infiltrate the mitochondria and thus make
a tangible difference.

To date, there are over 200 published research papers globally that detail MitoQ’s effect. Two human trials
are currently underway with four more scheduled for 2016. MitoQ supplement and skincare serum have
earned an international following for their energy enhancing health and anti-aging benefits for both healthy
and unwell people.

Antioxidant drug knocks down multiple sclerosis-like disease in mice

12/26/13 Portland, Ore.

Researchers at Oregon Health & Science University have discovered that an antioxidant designed by scientists more than a dozen years ago to fight damage within human cells significantly helps symptoms in mice that have a multiple sclerosis-like disease.

The antioxidant — called MitoQ — has shown some promise in fighting neurodegenerative diseases. But this is the first time it has been shown to significantly reverse an MS-like disease in an animal.

The discovery could lead to an entirely new way to treat multiple sclerosis, which affects more than 2.3 million people worldwide.

Multiple sclerosis occurs when the body's immune system attacks the myelin, or the protective sheath, surrounding nerve fibers of the central nervous system. Some underlying nerve fibers are destroyed. Resulting symptoms can include blurred vision and blindness, loss of balance, slurred speech, tremors, numbness and problems with memory and concentration.

The antioxidant research was published in the December edition of Biochimica et Biophysica Acta Molecular Basis of Disease. The research team was led by P. Hemachandra Reddy, Ph.D., an associate scientist in the Division of Neuroscience at OHSU's Oregon National Primate Research Center.

To conduct their study, the researchers induced mice to contract a disease called experimental autoimmune encephalomyelitis, or EAE, which is very similar to MS in humans. They separated mice into four groups: a group with EAE only; a group that was given the EAE, then treated with the MitoQ; a third group that was given the MitoQ first, then given the EAE; and a fourth "control" group of mice without EAE and without any other treatment.

After 14 days, the EAE mice that had been treated with the MitoQ exhibited reduced inflammatory markers and increased neuronal activity in the spinal cord — an affected brain region in MS — that showed their EAE symptoms were being improved by the treatment. The mice also showed reduced loss of axons, or nerve fibers and reduced neurological disabilities associated with the EAE. The mice that had been pre-treated with the MitoQ showed the least problems. The mice that had been treated with MitoQ after EAE also showed many fewer problems than mice who were just induced to get the EAE and then given no treatment.

"The MitoQ also significantly reduced inflammation of the neurons and reduced demyelination," Reddy said. "These results are really exciting. This could be a new front in the fight against MS.”

Even if the treatment continues to show promise, testing in humans would be years away. The next steps for Reddy's team will be to understand the mechanisms of MitoQ neuroprotection in different regions of the brain, and how MitoQ protects mitochondria within the brain cells of the EAE mice. Mitochondria, components within all human cells, convert energy into forms that are usable by the cell.

There is a built-in advantage with MitoQ. Unlike many new drugs, MitoQ has been tested for safety in numerous clinical trails with humans. Since its development in the late 1990s, researchers have tested MitoQ's ability to decrease oxidative damage in mitochondria.

“It appears that MitoQ enters neuronal mitochondria quickly, scavenges free radicals, reduces oxidative insults produced by elevated inflammation, and maintains or even boosts neuronal energy in affected cells,” said Reddy. The hope has been that MitoQ might help treat neurodegenerative diseases like Alzheimer's and Parkinson's. Studies evaluating its helpfulness in treating those diseases are ongoing.

Peizhong Mao, Ph.D., assistant professor of physiology and pharmacology in the OHSU School of Medicine, Maria Manczak, Ph.D., a research associate at ONPRC, and Ulziibat Shirendeb, Ph.D., a former postdoctoral scientist at ONPRC, are co-authors on Reddy’s study.

The research was funded by the National Institutes of Health (grants AG028072, AG042178 and RR000163) – and a grant from Vertex Pharmaceuticals.

About ONPRC

The ONPRC is one of the eight National Primate Research Centers supported by NIH. ONPRC is a registered research institution, inspected regularly by the United States Department of Agriculture. It operates in compliance with the Animal Welfare Act and has an assurance of regulatory compliance on file with the National Institutes of Health. The ONPRC also participates in the voluntary accreditation program overseen by the Association for Assessment and Accreditation of Laboratory Animal Care International (AAALAC).

About OHSU

Oregon Health & Science University is a nationally prominent research university and Oregon’s only public academic health center. It serves patients throughout the region with a Level 1 trauma center and nationally recognized Doernbecher Children’s Hospital. OHSU operates dental, medical, nursing and pharmacy schools that rank high both in research funding and in meeting the university’s social mission. OHSU’s Knight Cancer Institute helped pioneer personalized medicine through a discovery that identified how to shut down cells that enable cancer to grow without harming healthy ones. OHSU Brain Institute scientists are nationally recognized for discoveries that have led to a better understanding of Alzheimer’s disease and new treatments for Parkinson’s disease, multiple sclerosis and stroke. OHSU’s Casey Eye Institute is a global leader in ophthalmic imaging, and in clinical trials related to eye disease.

Novel antioxidant makes old arteries seem young again, study shows

Date:
May 6, 2014
Source:
University of Colorado at Boulder

Lab mouse (stock image). “One of the hallmarks of primary aging is endothelial dysfunction,” said Rachel Gioscia-Ryan, a doctoral student in CU-Boulder’s Department of Integrative Physiology and lead author of the new study. “MitoQ completely restored endothelial function in the old mice. They looked like young mice.”
An antioxidant that targets specific cell structures -- mitochondria -- may be able to reverse some of the negative effects of aging on arteries, reducing the risk of heart disease, according to a new study by the University of Colorado Boulder.

When the research team gave old mice -- the equivalent of 70- to 80-year-old humans -- water containing an antioxidant known as MitoQ for four weeks, their arteries functioned as well as the arteries of mice with an equivalent human age of just 25 to 35 years.

The researchers believe that MitoQ affects the endothelium, a thin layer of cells that lines our blood vessels. One of the many functions of the endothelium is to help arteries dilate when necessary. As people age, the endothelium is less able to trigger dilation and this leads to a greater susceptibility to cardiovascular disease.

"One of the hallmarks of primary aging is endothelial dysfunction," said Rachel Gioscia-Ryan, a doctoral student in CU-Boulder's Department of Integrative Physiology and lead author of the new study. "MitoQ completely restored endothelial function in the old mice. They looked like young mice."

The study, published in the Journal of Physiology, was funded by the National Institute on Aging, one of the 27 institutes and centers of the National Institutes of Health and a leader in the scientific effort to understand the nature of aging.

To trigger blood vessel dilation, the endothelium makes nitric oxide. As we age, the nitric oxide meant to cause dilation is increasingly destroyed by reactive oxygen species such as superoxide, which are produced by many components of our body's own cells, including organelles called mitochondria.

In a double-whammy, superoxide also reacts directly with the enzyme that makes nitric oxide, reducing the amount of nitric oxide being produced to begin with. All of this means less blood vessel dilation.

Even in the young and healthy, mitochondria produce superoxide, which is necessary in low levels to maintain important cellular functions. Superoxide is kept in check by the body's own antioxidants, which combine with superoxide to make it less reactive and prevent oxidative damage to cells.

"You have this kind of balance, but with aging there is this shift," said Gioscia-Ryan, who works in Professor Douglas Seals' Integrative Physiology of Aging Laboratory at CU-Boulder. "There become way more reactive oxygen species than your antioxidant defenses can handle."

That phenomenon, known as oxidative stress, occurs when the cells of older adults begin to produce too much superoxide and other reactive oxygen species. Mitochondria are a major source of superoxide in aging cells. The increased superoxide not only interacts with nitric oxide and the endothelium, but can also attack the mitochondria themselves. The damaged mitochondria become increasingly dysfunctional, producing even more reactive oxygen species and creating an undesirable cycle.

Past studies have looked at whether taking antioxidant supplements long term could improve vascular function in patients with cardiovascular disease by restoring balance to the levels of superoxide, but they've largely shown that the strategy isn't effective.

This new study differs because it uses an antioxidant that specifically targets mitochondria. Biochemists manufactured MitoQ by adding a molecule to ubiquinone (also known as coenzyme Q10), a naturally occurring antioxidant. The additional molecule makes the ubiquinone become concentrated in mitochondria.

"The question is, 'Why aren't we all just taking a bunch of vitamin C?" Gioscia-Ryan said. "Scientists think that, taken orally, antioxidants like vitamin C aren't getting to the places where the reactive oxygen species are being made. MitoQ basically tracks right to the mitochondria."

The findings of the study indicate that the strategy of specifically targeting the mitochondria may be effective for improving the function of arteries as we age. In addition to improving endothelial function, the MitoQ treatment increased levels of nitric oxide, reduced oxidative stress and improved the health of the mitochondria in the arteries of old mice.

Story Source:

The above story is based on materials provided by University of Colorado at Boulder. Note: Materials may be edited for content and length.

MitoQ can help when you are healthy. MitoQ is suitable for healthy adults who want to slow the processes associated with aging, and stay well. MitoQ can help when you are not MitoQ is also suitable for adults with health conditions associated with mitochondrial dysfunction and oxidative stress imbalances and the oxidative stress associated with being overweight. MitoQ offers benefits for everyone, for optimal health and longevity it should be part of a lifestyle that includes a healthy diet and regular exercise. New advanced and patented CoQ antioxidant technology Targets mitochondria, the cellular power plant Improves energy levels MitoQ is a patented antioxidant that targets the mitochondria, our cellular power plant, to support optimal cell function and heart, liver and brain health. MitoQ also boosts energy, and reduces the cellular free radical damage that, over time, causes us to age and can manifest as disease.Levels of Cellular CoQ (aka CoQ10, ubiquinone or ubiquinol) decline from age 20, so many people supplement with CoQ to assist energy levels, to support certain health conditions, and when taking medicines that deplete CoQ (like statins for heart disease).

Unfortunately, most CoQ formulas do not reach the mitochondria at levels that are needed.MitoQ is different. It has been designed to replenish antioxidant levels in the mitochondria and in so doing assists the cell with repair and regular function, and acts as an antioxidant reservoir to reduce the damage that excess free radicals cause to DNA and cell membranes.MitoQ, when taken with a good diet and regular exercise, will support healthy aging.oxidative stress.

MitoQ's patented technology delivers powerful antioxidant support to mitochondria, the power source of your cells, restoring their vitality so they can fight the symptoms of aging and support organ health.. New advanced and patented CoQ antioxidant technology Targets mitochondria, the cellular power plant. Improves energy levels. Supports optimal organ health. Slows free radical damage associated with Aging Over a decade of research. MitoQ is an exciting advance in CoQ antioxidant technology that has been extensively researched over the last decade. Research has focused on its beneficial effects for people with poor mitochondrial function, including brain, liver and heart disease, and diabetes. The results show that by delivering targeted support to mitochondria, the powerful organelles found in every cell in your body,

MitoQ has a positive impact on specific health conditions and overall health.MitoQ is also considered to have significant potential as an anti-aging compound because it reduces gradual free radical damage to cellular machinery, cell walls and DNA, slowing the aging process.While MitoQ offers benefits for everyone, for optimal health and longevity it should be part of a lifestyle that includes a healthy diet and regular exercise. MitoQ delivers antioxidant protection to your mitochondria, your 'cellular batteries', 847 x more effectively than any other CoQ form Because you age at the cellular level… Your cells know how to look after you, they just need a bit of help. Every cell in your body is powered by small organelles called mitochondria. They take glucose from the food you eat and oxygen from the air you breathe and convert them into the energy your cells need to keep your organs functioning.

Mitochondria also co-ordinate cell communication, cell death, cell growth and cell differentiation, and use antioxidants to fight the effects of free radical damage and oxidation. At the cellular level, mitochondria call the shots, so you need to keep them healthy. Because aging starts at twenty… As you age your mitochondria do too. From the age of twenty, antioxidant supplies decline, meaning mitochondria can’t fight off free radicals as well as they used to and oxidation sneaks in.You notice it in your skin first, but it’s happening in your other organs too. As oxidative stress damages the cells in your skin and other organs you might start to look and feel older. Until now, the best way to support mitochondria was to take CoQ supplements. But while CoQ supplements do help, they have been unable to deliver CoQ to the mitochondria at levels that make a real difference. Because MitoQ can help.

MitoQ is a Mitochondrial Targeted Antioxidant that delivers antioxidant CoQ directly to your mitochondria, supporting their natural function and restoring their health. This means they can get on with their job, eliminating free radicals, preventing oxidation, and keeping your skin and organs healthy. MitoQ does this 847 times more effectively than any other CoQ formulation on the market. Because when you recharge your cells, you recharge your life… The effect? Your cells start to act and look young. MitoQ supports your mitochondria, your cellular power plant or batteries. It protects mitochondria from damage caused by the free radicals that they generate when they make energy to run your cells. When you protect and support your energy source each of your cells literally has more energy to do its job, whether it's in your heart as it pumps day in and day out, in your brain keeping your brain sharp, or in your liver taking the toxins out of your system · . But what does it really mean?

People that take MitoQ supplements report extra energy, less stress, support for sleep, increased endurance, increased libido and an overall feeling of good health. We all have different levels of oxidative stress and mitochondrial function, so we will all experience a different effect. For some, the benefits of MitoQ may include sharper thinking, for others they may mean a more settled stomach. Those people already in good health may feel nothing to begin with, but you will benefit over time as free radical levels decline and MitoQ reduces the gradual damage to your cells known as aging.

Mitochondria are life-giving organelles found in every cell in our body. They provide energy to our cells so that they work in an optimal way, and they fight the oxidative stress caused by free radicals. When cells work optimally we experience good health. Mitochondria are found in the highest numbers in organ cells that consume the most energy, like our skin, heart, brain and liver. Mitochondrial function within these cells depends on the antioxidant support our bodies supply. From the age of twenty our antioxidant levels decline and mitochondrial function declines too.Over 200 conditions are now known to be associated with poor mitochondrial function, including brain, liver and heart disease, and diabetes. Even if you are in perfect health, this gradual loss of mitochondrial function means that as you age your cells don't get the energy they need, leading to sub-optimal function and gradual health decline. MitoQ is the first antioxidant supplement to reach mitochondria at levels that make a difference. When cellular energy generation is restored, cells are able to regenerate.

Antioxidant drug knocks down multiple sclerosis-like disease in mice

12/26/13 Portland, Ore.

Researchers at Oregon Health & Science University have discovered that an antioxidant designed by scientists more than a dozen years ago to fight damage within human cells significantly helps symptoms in mice that have a multiple sclerosis-like disease.

The antioxidant — called MitoQ — has shown some promise in fighting neurodegenerative diseases. But this is the first time it has been shown to significantly reverse an MS-like disease in an animal.

The discovery could lead to an entirely new way to treat multiple sclerosis, which affects more than 2.3 million people worldwide.

Multiple sclerosis occurs when the body's immune system attacks the myelin, or the protective sheath, surrounding nerve fibers of the central nervous system. Some underlying nerve fibers are destroyed. Resulting symptoms can include blurred vision and blindness, loss of balance, slurred speech, tremors, numbness and problems with memory and concentration.

The antioxidant research was published in the December edition of Biochimica et Biophysica Acta Molecular Basis of Disease. The research team was led by P. Hemachandra Reddy, Ph.D., an associate scientist in the Division of Neuroscience at OHSU's Oregon National Primate Research Center.

To conduct their study, the researchers induced mice to contract a disease called experimental autoimmune encephalomyelitis, or EAE, which is very similar to MS in humans. They separated mice into four groups: a group with EAE only; a group that was given the EAE, then treated with the MitoQ; a third group that was given the MitoQ first, then given the EAE; and a fourth "control" group of mice without EAE and without any other treatment.

After 14 days, the EAE mice that had been treated with the MitoQ exhibited reduced inflammatory markers and increased neuronal activity in the spinal cord — an affected brain region in MS — that showed their EAE symptoms were being improved by the treatment. The mice also showed reduced loss of axons, or nerve fibers and reduced neurological disabilities associated with the EAE. The mice that had been pre-treated with the MitoQ showed the least problems. The mice that had been treated with MitoQ after EAE also showed many fewer problems than mice who were just induced to get the EAE and then given no treatment.

"The MitoQ also significantly reduced inflammation of the neurons and reduced demyelination," Reddy said. "These results are really exciting. This could be a new front in the fight against MS.”

Even if the treatment continues to show promise, testing in humans would be years away. The next steps for Reddy's team will be to understand the mechanisms of MitoQ neuroprotection in different regions of the brain, and how MitoQ protects mitochondria within the brain cells of the EAE mice. Mitochondria, components within all human cells, convert energy into forms that are usable by the cell.

There is a built-in advantage with MitoQ. Unlike many new drugs, MitoQ has been tested for safety in numerous clinical trails with humans. Since its development in the late 1990s, researchers have tested MitoQ's ability to decrease oxidative damage in mitochondria.

“It appears that MitoQ enters neuronal mitochondria quickly, scavenges free radicals, reduces oxidative insults produced by elevated inflammation, and maintains or even boosts neuronal energy in affected cells,” said Reddy. The hope has been that MitoQ might help treat neurodegenerative diseases like Alzheimer's and Parkinson's. Studies evaluating its helpfulness in treating those diseases are ongoing.





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