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5-LOX Inhibitor with AprèsFlex 100 mg 60 vegetarian capsules

7-Keto DHEA Metabolite 100 mg, 60 vegetarian capsules

7-Keto DHEA 100 mg 120 Vcaps

7-Keto DHEA 100 mg 60 vcaps

Acetyl-L-Carnitine 500 mg 100 vegetarian capsules

Acetyl-L-Carnitine Arginate 100 vegetarian capsules 100 vegetar

Adrenal Energy Formula 120 vegetarian capsules

Adrenal Energy Formula 60 vegetarian capsules

Advanced Anti-Adipocyte Formula 60 vegetarian capsules

Advanced Lipid Control 60 vegetarian capsules

Advanced Natural Appetite Suppress 60 vegetarian capsules

Advanced Olive Leaf Vascular Support with Celery Seed Extract 60

Advanced Oral Hygiene 60 mint lozenges

Algae Omega 60 gels

AMPK Metabolic Activator

Anti-Aging Rejuvenating Scalp Serum 2 oz (60 ml

Anti-Aging Rejuvenating Scalp Serum 2 oz (60 ml)

AppleWise Polyphenol Extract 600 mg 30 vegetarian capsules

Arginine Caps 700 mg 200 vegetarian capsules

Arginine Ornithine Powder 150 grams (5.29 oz)

Arterial Protect 30 vegetarian capsules

Arthromax™ Advanced with UC-II® & AprèsFlex® 60 capsules

ArthroMax® Herbal Joint Formula

Arthroplex 190 caps Thorne Research

Ashwagandha Extract Oimized t (Stimulant Free)

Asian Energy Boost 90 vegetarian capsules

Astaxanthin BioAstin Astaxanthin 12mg 50 Gelcap

Astaxanthin with Phospholipids 4 mg 30 softgels

Athletic Nutrients 180 Capsules Pure Encapsulations

Bacopa -- 60 Vegetarian Capsules

Bacopa 60 Vegetarian Capsules

BCAA Powder 227 Grams Pure Encapsulations

Benfotiamine (Mega) 250 mg, 120 vegetarian capsules)

Benfotiamine With Thiamine 100 mg, 120 vegetarian capsules

Berberine 500 mg 60 caps

Berry Complete Enhanced Berry Complete with Açaí

Beta Glucan & Aloe Skin Renewal Anti-Aging Cream 2 oz With WGP®

Beta Glucan 500 mg 100 caps

BetterWOMAN® 40 capsules

Bifido GI Balance

BioSil Skin, Hair, Nails 120 vcaps

Biosil Skin, Hair, Nails 30 vcaps

BioSil Skin, Hair, Nails 60 vcaps

BioSil Beauty, Bones, Joints 1 fl oz

Biotin 600 mcg, 100 capsules

Black Cumin Seed Oil 60 softgels

Black Cumin Seed Oil with Bio-Curcumin® 60 softgels

Black Seed, Cold-Pressed Oil, 8 fl oz Amazing Herbs

Blood PressureTriple Action Blood Pressure 60 vegetarian tablet

Blood Presure Natural BP Management 60 tablets

Blueberry Extract with Pomegranate 60 vegetarian capsules

Bluebonnet Calcium Magnesium Potassium 90 caplets

Bone Restore 120 capsules

Bone Restore with Vitamin K2 150 Capsules

Bone Strength Formula with KoAct® 120 capsules

Booster Once-Daily Health Booster 60 softgels

Boron 3 mg, 100 vegetarian capsules

Brain Shield 60 vegetarian capsules

Branched Chain Amino Acids (Free Form) 90 capsules

Brassica Green Tea with SGS

Brite Eyes III

Broccoli Sprout Cream

Buffered Vitamin C Powder 454 grams (16 oz)

CalApatite Bone Builder Forte 180 caps

Calcium & Magnesium 120 tablets

California Estate Organic Extra Virgin Olive

CalReduce Selective Fat Binder

Canine Basic Nutrients 120 Capsules

Canine Geriatric Basics 120 caps Thorne Research

Canine Geriatric Basics 120 Capsules

Cardio Peak™ with Standardized Hawthorn and Arjuna 120 ve

Carnitine Optimized Carnitine with GlycoCarn® 60 vegetarian

Carnosine Super Carnosine 500 mg 60 vegetarian capsules

CDP-Choline Caps 250 mg 60 vegetarian capsules

CHOL-Support 60 liquid vegetarian capsules

Cholestene 120 Capsules

CinSulin® with InSea2® and Crominex

CLA Blend with Guarana and Sesame Lignans (Super) 1000 mg, 120 s

CLA Super CLA Blend with Sesame Lignans 1000 mg, 120 softgels

CocoaMind 14 single-serving packets

CoffeeGenic® Green Coffee Extract 200 mg 90 Veg Caps

Cognitex with Brain Shield 90 softgels

Cognitex with Pregnenolone & Brain Shield 90 softgels

Collagen Bio-Collagen with Patented UC-II® 40 mg, 60 small cap

Collagen Super Collagen+C

Comprehensive Nutrient Packs ADVANCED 30 packets

CoQ10 SuperUbiquinol CoQ10 with Enhanced Mitochondrial 200mg

CoQ10 Super Ubiquinol CoQ10 with Enhanced Mitochondrial 100mg 6

CoQ10 Super Ubiquinol CoQ10 with BioPQQ 100 mg 30 softgels

Cran-Max Optimized with UTIRose 60 Veg Caps

Cran-Max® Cranberry Whole Fruit Concentrat500 mg, 60 vegetar

Creatine Capsules 120 vegetarian capsules

Curcumin Advanced Bio-Curcuminwith Ginger & Turmerones

Curcumin(Super Bio-Curcumin®) 400 mg, 60 vegetarian capsules

Cytokine Suppress 30 vegetarian capsules

D-Ribose Powder 150 grams

DHA Vegetarian Sourced DHA 30 vegetarian softgels

DHEA (Dehydroepiandrosterone) 100 mg 60 vegetarian capsules

DHEA (Dehydroepiandrosterone) 25 mg 100 dissolve in mouth tablet

DHEA (Dehydroepiandrosterone) 25 mg, 100 capsules

DHEA (Dehydroepiandrosterone) 50 mg 60 capsules

DHEA (Dehydroepiandrosterone)15 mg 100 capsules

DHEA Complete 60 vegetarian capsules

Digestion Enhanced Super Digestive Enzymes With Probiotics

Dim 150 ( 60 Capsules)Bio Response

DMAE Bitartrate 150 mg 200 vegetarian capsules

DNA Protection Formula 60 vegetarian capsules

Dog Mix 100 grams (3.52 oz)

Dopa-Mind 60 vegetarian tablets

Elderberry Instant Immune POW-der

Endothelial Defense with Full-Spectrum Pomegranate and CORDIAR

Enhanced Fernblock® with Red Orange Complex

Enzalase 50 caps

Esophageal Guardian Natural Berry Flavor 60 chewable tablets

European Leg Solution featuring Certified Diosmin 95 600 mg 30 v

Evening Primrose Oil 1300 mg 120 gels

Extraordinary Enzymes 60 Capsules

Eye Pressure Support with Mirtogenol 30 vegetarian capsules

Fiber Garden of Life, RAW Fiber, Beyond Organic Fiber, 1.77 lbs

Fibrinogen Resist

Fish Oil Super Omega-3 EPA/DHA Sesame Lignan Olive Frut 120

Fish Oil Super Omega-3 EPA/DHA Sesame Lignan Olive Frut 240

Fish Oil Enteric coated softgels Super Omega-3 EPA/DHA withSesa

Fish Oil Super Omega with Krill & Astaxanthin 120 softgels

Florasone Cream 1 oz

Florassist Mood 60 capsules

Florassist Balance 30 liquid vegetarian capsules

Florassist Throat Health 30 lozenges

Florassist ® Oral Hygiene30 lozenges

FLORASSIST® GI with Phage Technology

FlorAssist® Heart Health Probiotic 60 vegetarian capsu

Folate High Potency Optimized Folate L-Methylfolate 5

Folate Optimized Folate (L-Methylfolate) 1000 mcg 100 vegetarian

Formula SF722 Thorne Research

Forskolin 10 mg, 60 vegetarian capsules

G.I. Benefits 30 servings Davinci Labs

Garcinia Cambogia,Garcinia HCA 90 vegetarian capsules

Garlic Optimized Garlic 200 vegetarian capsules

Gastro-Ease

Ginkgo Biloba, 120 Veggie Caps Paradise Herbs

Glucosamine/Chondroitin Capsules 100 Capsules

Glucosamine/Chondroitin Capsules 100 capsules

Glutamine L-Glutamine 500 mg 100 capsules

Glutamine L-Glutamine Powder 100 grams (3.52 oz)

Glutathione Powder 50 Grams

Glutathione Powder 50 Grams Special Buy 5 get one bottle free

Glycemic Guard 30 vegetarian capsules

Glycine 1000 mg, 100 capsules

Glycine Powder 1 lb Now

Green Tea Green Tea Extract (Lightly Caffeinated) 100 vegetarian

Green Tea Mega Green Tea Extract (Decaffeinated)100 vegetarian

GreenTea 70

Hair, Skin & Nails Rejuvenation Formula with VERISOL® 90 tablets

HepatoPro (Polyunsaturated Phosphatidylcholine) 900 mg 60 sof

Holy Basil Force 120 softgels

Hyaluronic Acid 180 Capsules Pure Encapsulations

Hydrating Anti-Oxidant Face Mist 4 oz

Iberogast ( Medical Futures Inc)

Immune Protect with Paractin

Immune Senescence Protection Formula™

Innate Detox™ 90 Caps

Inositol Capsules 1000mg 360 capsules

Inositol Powder Net Weight 16 oz

Iodine Sea-Iodine 1000 mcg 60 capsules

Iodoral Vitamin Research 180 tablets

Iron Protein Plus 300 mg 100 capsules

Italian Borlotto variety bean extract Advanced Natural Appetite

Joint Formula Fast-Acting 30 Capsules

Krill Healthy Joint Formula 30 softgels

L--Lysine 620 mg 100 vegetarian Capsules

L-Carnitine 500 mg 30 vegetarian capsules

L-Citrulline 600 mg 100 caps

L-Citrulline Powder 100 gms Nutricology/ Allergy Research

Lecithin 1200 mg 100 gels

Lecithin 97% Phosphatides De-Oiled 454 grams (1 lb or 16 oz)

Liquid Calcium Magnesium Citrate Plus Vitamin D3 (blueberry)

Liquid Glucosamine 1500-Chondroitin-MSM 16oz Dr's Advantage

Liquid Vitamin D3

Lithium 5mg

MacuGuard™ Ocular Support wIth Astaxanthin 60 softgels

Magnesium (Citrate)

Magnesium Caps 500mg 100 Capsules

Magnesium Neuro-Mag™ Magnesium L-Threonate 90 vegetarianca

Magnesium Neuro-Mag® Magnesium L-Threonate Tropical Punch Flavor

Mediterranean Trim with Sinetrol 60 vegetarian capsules

Melatonin 6 Hour Timed Release 3 mg 60 vegetarian tablets

Melatonin 10 mg 60 capsules

Melatonin 3 mg 60 capsules

Melatonin 3 mg 60 vegetarian lozenges

Melatonin 6 Hour Timed Release 750 mcg 60 vegetarian tablets

Melatonin Fast-Acting Liquid Melatonin

Migra-Eeze™Standardized Butterbur-Ginger-Riboflavin Formula

Milk Thisle Certified European Milk Thistle 120 softgels

Milk Thistle Certified European Milk Thistle 60 vegetarian c

Mitochondrial Energy Optimizer with BioPQQ® 120 capsules

MitoQ 5mg Vegicaps

MitoQ® 5mg Vegicaps Triple Pack

MitoQ® Moisturizing Anti-Aging Serum 1.7FL oz (50ml

Monolaurin 600 mg 90 caps Ecological Formulas

Multi Vitamin Children's Chewable120 Chewable Tablet

Multi Vitamins Life Extension One-Per-Day Tablets 60 tablets

Multi Vitamins Life Extension Two-Per-Day Tablets 60 tablets

Multi Vitamins Life Extension Mix Powder without Copper 420gra

Multi Vitamins Life Extension Mix Capsules without Copper 490ca

Multi Vitamins Life Extension Mix Tablets 315 tablets

Multi Vitamins Life Extension Mix Tablets without Copper 315 ta

Multi Vitamins Life Extension Mix™ Capsules 490 capsules

Multi Vitamins Life Extension Mix™ Powder 420 grams (14.81 oz)

Multi Vitamins Two-Per-Day Capsules 120 capsules

Multi Vitamins Two-Per-Day Tablets 120 tablets

Mung Bean Soup with Turmeric

N-Acetyl-L-Cysteine 600 mg, 60 vegetarian capsules

N-Acetyl-L-Cysteine600 mg, 60 vegetarian capsules

NAD+ Cell Regenerator250 mg, 30 vegetarian capsules

NAD+ Cell Regenerator™ Nicotinamide Riboside

Natural Estrogen 60 vegetarian tablets

Natural Sleep Melatonin 5 mg 60 vegetarian capsules

Natural Sleep® 60 vegetarian capsules Melatonin 3 mg

Natural Stress Relief 30 vegetarian capsules

Niacin (No Flush) (Inositol Hexanicotinate) 800 mg 100 capsules

Nordic Naturals Berries 200 Chews

Nordic Naturals Omega-3 Worms 30 worms

Nordic Naturals, Ultimate Omega, Lemon Flavor, 1000 mg, 180 Soft

Nordic Omega-3 Gummies

Optimized Fucoidan with Maritech® 926

Optimized Irvingia with Phase 3 Calorie Complex

OrganoGermanium 100 mg 100 tabs

Pantothenic Acid (Vitamin B5) 500 mg 100 capsules

Phosphatidylserine Lef PS Caps 100mg 100 capsules

Plant Protein Complete & Amino Acid Complex Vanilla Flavor

PMS Support (Chaste Tree Dandelion), 340 mg, 45 Veggie Caps

Policosanol 10 mg 60 tablets

PQQ Caps with BioPQQ 20 mg 30 vegetarian capsules

PQQ Caps with BioPQQ10 mg 30 vegetarian capsules

Pregnenolone 100mg 100 capsules

Pregnenolone 50mg 100 capsules

Prelox Natural Sex for Men® 60 tablets

Probiotic Dr. Ohhira\'s Probiotics 12 Plus, Professional Formul

ProDHA Eye 120 gels

Prostate Ultra Natural Prostate softgels

PROVINAL Omega-7 PROVINAL® Purified Omega-7 30 softgels

Pycnogenol® 100 mg 60 vegetarian capsules

Quercetin Optimized Quercetin 250 mg 60 vegetarian capsules

R-Lipoic Acid Super R-Lipoic Acid 300 mg 60 vegetarian capsules

Reishi Extract Mushroom Complex

RejuveneX® Factor Firming Serum 1.7 oz (50 ml)

Resveratrol Optimized NAD+ Cell Regenerator

Resveratrol Optimized Resveratrol

Resveratrol Optimized Resveratrol with Nicotinamide Riboside

Rhodiola Extract (3% Rosavins)250 mg, 60 vegetarian capsules

RiboGen French Oak Wood Extract 200 mg, 30 vegetarian capsules

SAMe (S-Adenosyl-Methionine) 200 mg 20 enteric coated tablets

SAMe (S-adenosyl-methionine) 400 mg 50 enteric coated tablets

SAMe (S-adenosyl-methionine) 400mg 20 tablets

SAMe (S-adenosyl-methionine)200 mg, 50 tablets

Saw Palmetto 60 gels Standardized

Skin Restoring Phytoceramides with Lipowheat 30 veg liquid caps

Skin Stem Cell Serum 1 oz

Skin Tone Equalizer

Spectra Greens 9.95 Ounces Powder Davinci

SPECTRA PURPLES

SPECTRA REDS

Stem Cell Cream with Alpine Rose 1 oz

Strontium Caps 750 mg, 90 vegetarian capsules

Sun Glasses (OveRxCast Polarized Sunglasses) designed to be worn

Super MiraForte with Standardized Lignans 120 capsules

Super Selenium Complex 200 mcg & Vitamin E 100 vegetarian ca

Tart Cherry Extract 60 vegetarian capsules

Taurine 1000 mg, 50 capsules Life Extension

Taurine L-Taurine Powder 300 grams (10.58 oz.)

Tear Support with MaquiBright & Maqui Berry Extract

Theanine L-Theanine 100 mg 60 vegetarian capsules

Theralac 30 caps

Thyroid Triple Action Thyroid 60 vegetarian capsules

TMG 500 mg, 60 liquid vegetarian capsules

TMG Powder 50 grams (1.76 oz)

Tocotrienols Super-Absorbable Tocotrienols 60 softgels

Tocotrienols with Sesame Lignans 60 softgels

Tooth Paste Life Extension Toothpast

Trace Minerals Only Trace Minerals 90 vegetarian capsules

Tranquil Tract 60 vegetarian capsules

Tri Sugar Shield 60 vegetarian capsules

Triple Action Cruciferous Vegetable Extract 60 vegetarian capsul

Triple Action Cruciferous Vegetable Extract with Resveratrol 60

TruFlora 32 vcaps

Tryptophan L-Tryptophan Optimized Tryptophan Plus

Tryptophan L-Tryptophan 500 mg 90 vegetarian capsules

Turmeric Force, 60 Softgel Capsules New Chapter

Ultra Nutrient 180 Vcaps Pure Encapsulations

Ultra Nutrient 360 Vcaps Pure Encapsulations

Ultra Rejuvenex® 2 oz jar

Under Eye Refining Serum Darkness · Puffiness · Fatigue 0.5 oz

Under Eye Rescue Cream 0.5 oz

Under Eye Serum Advanced Under Eye Serum with Stem Cells 0.33 oz

Uric Acid Control 60 vegetarian capsules

Valerian Extended Release 600 mg 30 tablets

VenoFlow30 vegetarian capsules

Venotone 60 capsules

Vitalica Extra Strength Physicians Formula 60 Capsules

Vitalica Plus, Enzyme Activated Broccoli Supplement, 30 Capsules

Vitamin B BioActive Complete B-Complex 60 vegetarian capsules

Vitamin B-Complex Plus 60

Vitamin B12 (Methylcobalamin) 5mg 60 lozenges

Vitamin B6 Pyridoxal 5'-Phosphate Caps 100 mg 60 veg caps

Vitamin C Effervescent Vitamin C - Magnesium Crystals

Vitamin C Fast-C® with Dihydroquercetin 120 vegetarian tablets

Vitamin C Powder (Buffered) 454.6 grams

Vitamin C with Dihydroquercetin 1000 mg, 250 tablets

Vitamin D Lotion 4 oz

Vitamin D3 (Liquid Emulsion

Vitamin D3 10,000 IU 60 vcaps

Vitamin D3 10,000 with K2 60 Metagenics

Vitamin D3 1000 IU, 250 capsules

Vitamin D3 5000 IU 60 Softgels

Vitamin D3 5000 IU 250 vcaps

Vitamin D3 7,000 IU 60 softgels

Vitamin D3 with Sea-Iodine5,000 IU, 60 capsules

Vitamin E Gamma E Tocopherol with Sesame Lignans

Vitamin E Gamma E Tocopherol/Tocotrienols

Vitamin E Unique E 120 softgels

Vitamin K Low-Dose Vitamin K2 45 mcg 90 softgels

Vitamin K Healing Vitamin K Cream

Vitamin K Super K)With Advanced K2 Complex

Vitamin KLow-Dose Vitamin K2 45 mcg, 90 softgels

Vitamins D and K with Sea-Iodine 60 capsules

Waist-Line Control 120 vegetarian capsules

Water-Soluble Pumpkin Seed Extract 60 vegetarian capsules

Whey Protein Isolate (Natural Chocolate Flavor) 454 grams (1 lb.

Whey Protein Isolate (Natural Vanilla Flavor) 454 grams (1 lb. o

Whey Protein New Zealand Whey Protein Concentrate Natural Chocol

Whey Protein New Zealand Whey Protein Concentrate Natural Vanill

Youth Serum 1 oz

Yummi Bears Organic Multivitamin 90 Gummies Hero

Zinc Caps High Potency 50 mg 90 vegetarian capsules

Zyflamend Prostate 60 gels

Zyflamend® Whole Body 120 softgels


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Glutathione Powder 50 Grams Special Buy 5 get one bottle free $375.00

This Glutathione is made by Kohjin for Talking Herbals They have been making Glutathione since 1968. One level teaspoon is 1500mg. There is approximately 33 servings per bottle. This is the purest Glutathione available today. Talking Herbals has been selling it since 1999.

Clinical Tests Demonstrate Long-Term Effectiveness of Oral Glutathione Supplements Penn State College of Medicine researchers say supplementation can increase body’s glutathione stores.



We believe GSH supplementation may represent an effective intervention strategy for disease prevention and may enhance immune function -- Dr. John P. Richie

Hershey, PA (PRWEB) April 25, 2013



Glutathione deficiency has been found to be virtually universal in autoimmune diseases. This deficiency has two major implications: detox failure and viral/microbial activation. Glutathione plays a major role in detoxification. This deficiency impairs the body’s ability to get rid of toxins.

Consequently, people slowly become toxic, storing away poisons in fatty tissue, muscles, organs and the brain. This cellular detox failure can make people canaries to their environment.

To detoxify successfully, this glutathione deficiency must be addressed.

Because glutathione is a potent antiviral and anti-microbial weapon, glutathione deficiency compromises antiviral and anti-microbial defenses, and actually stimulates viral replication. Raising glutathione levels inside the cells can stop the replication of almost any pathogen.

A glutathione deficiency compromises our ability to keep old viruses dormant and fight off bacteria. This is why so many people test positive for EBV, CMV, HHV6, Mycoplasma, and Chlamydia Pneumoniae, etc.

Indications are that glutathione can stop the replication of any intracellular microbe, including HHV6, Chlamydia Pneumoniae, and mycoplasma. .

There has been a good deal of research that show how important glutathione is.

Immune depressed individuals have lower glutathione levels when fighting disease. Lymphocytes, cells vital for your immune response, depend on glutathione for their proper function and replication. Immunology 61: 503-508 1987 .

Cellular depletion of Glutathione has been implicated as a causative, or contributory factor in many pathologies including Parkinson\'s, Alzheimer\'s, cataracts, arteriosclerosis, cystic fibrosis, malnutrition, aging, AIDS and cancer (Bounous et al., 1991).

In addition, Glutathione is essential in supporting the immune system, including natural killer cells (Droege et al., 1997) and in the maintenance of T-lymphocytes (Gutman, 1998).

It is known that as we age, there is a precipitous drop in glutathione levels. Lower Glutathione levels are implicated in many diseases associated with aging, including Cataracts, Alzheimer\'s disease, Parkinson\'s, atherosclerosis and others. Journal of Clinical Epidemiology 47: 1021-28 1994

Antioxidants are well documented to play vital roles in health maintenance and disease prevention. Glutathione is our cell\'s own major antioxidant. Why not use what is natural? Biochemical Pharmacology 47:2113-2123 1994

Low glutathione has been demonstrated in neurodegenerative diseases such as MS (Multiple Sclerosis), ALS (Lou Gehrig\'s Disease), Alzheimer\'s, and Parkinson\'s, among others. The Lancet 344: 796-798 1994

Glutathione detoxifies many pollutants, carcinogens and poisons, including many in fuel exhaust and cigarette smoke. It retards damage from radiation such as seen with loss of the ozone. Annual Review of Biochemistry 52: 711-780 1983.

The liver is the main detoxification organ of the body. In the liver we find very high concentrations of glutathione, as it is a major factor in numerous biochemical detoxification pathways. Numerous studies have demonstrated that patients with compromised liver function due to alcohol abuse have significant reduction of glutathione in the liver. (Lamestro, 1995)

Glutathione is essential for the maintenance of Vitamin C and vitamin E levels according to Martensson. He found that as glutathione levels decreased, a corresponding decrease in ascorbic acid and vitamin E followed, which led to systematic mitochondrial death, which in turn leads to a cessation of cellular metabolism.

(It is this mitochondrial death, at first just a dysfunction, that may cause the fatigue found in autoimmune illnesses.)

The over-toxicity causes extensive free radical damage. Inhibits cellular function. Disrupts energy production by the mitochondria. Consequently the primary energy the cells produce is anaerobic which leads to extensive lactic acid buildup in the cells. And more toxicity.

Cheney explains that fatigue becomes worse. Pain increases. You feel sicker. Memory suffers as toxins and free radicals damage the brain, and not enough oxygen gets into the brain. Deep brain structures like the hypothalamus eventually are injured and cause problems with virtually every hormone in your body. They lose their ability to rise and fall according to signals or demands from the body making it harder to respond to changing situations. Actual damage to the DNA of the energy producing mitochondria can occur. Further limiting energy.

As toxins cause free radical damage, you end up with low levels of all the free radical scavengers. They get used up dealing with excessive free radicals produced by the excessive toxins.

Glutathione is the body’s master antioxidant involved in protecting cells and tissues from oxidants and a large variety of other toxins and insults. Debate over whether orally administered glutathione could be effective at enhancing glutathione levels in cells and tissues has simmered for years. Now, a Penn State College of Medicine study shows oral supplementation is effective in increasing the body’s stores of this vital nutrient.

The study of 54 healthy adults revealed that glutathione (GSH) levels of those taking 1000mg of Glutathione a day for six months increased 30%-35% in many compartments including red blood cells, lymphocytes and plasma., Glutathione increased in whole blood. And as glutathione stores increased so did the function of natural killer (NK) cells, a marker for increased immune defense, said John P. Richie, Jr., Ph.D., professor of Public Health Sciences and Pharmacology at Penn State College of Medicine.

“A battery of immune function markers was examined after three months of glutathione supplementation and NK cytotoxicity was enhanced more than two-fold for participants taking 1000mg daily doses,” Dr. Richie said. “We believe GSH supplementation may represent an effective intervention strategy for disease prevention and may enhance immune function.”

There is a school of thought that contends that glutathione is broken down in the stomach and intestine and effective increases of GSH must come via intravenous administration. However, previous animal studies showed that orally administered glutathione is bioavailable and will enhance tissue GSH levels, Dr. Richie said.

“Our research showed that in most cases increases were dose and time dependent, and levels returned to baseline after a one-month washout,” he said. “By taking daily GSH supplements, we believe efficacious levels will persist, and that oral intake is an effective means of chronically enhancing the body’s stores.”

Dr. Richie presented the study findings – “Enhanced Glutathione Levels in Blood and Buccal Cells by Oral Glutathione Supplementation” – at the Experimental Biology 2013 conference in Boston on April 22. The study was a joint effort of the Pennsylvania Department of Public Health Sciences, the Penn State Hershey Cancer Institute, and the Penn State College of Medicine.

About John P. Richie, Ph.D.

Dr. Richie is professor, Public Health Sciences and Pharmacology, at Penn State College of Medicine, State College, Penn. He has researched has researched glutathione for more than 30 years, including its role in protecting against oxidative damage during aging and the development of cancer at numerous sites in the body. Dr. Richie\'s research focuses on the factors that regulate glutathione, oxidative stress and cancer risk in individuals and in various populations

What is Glutathione (GSH)?

Biochemistry and Metabolism:

Reduced Glutathione (GSH) is a linear tripeptide of L-glutamine, L-cysteine, and glycine. Technically N-L-gamma-glutamyl-cysteinyl glycine or L-Glutathione, the molecule has a sulfhydryl (SH) group on the cysteinyl portion, which accounts for its strong electron-donating character.

As electrons are lost, the molecule becomes oxidized, and two such molecules become linked (dimerized) by a disulfide bridge to form Glutathione disulfide or oxidized Glutathione (GSSG). This linkage is reversible upon re-reduction.

Glutathione is under tight homeostatic control both intracellularly and extracellularly. A dynamic balance is maintained between GSH synthesis, it’s recycling from GSSG/oxidized Glutathione, and its utilization.

Glutathione synthesis involves two closely linked, enzymatically-controlled reactions that utilize ATP. First, cysteine and glutamate are combined by gamma-glutamyl cysteinyl synthetase. Second, GSH synthetase combines gamma-glutamylcysteine with glycine to generate Glutathione. As Glutathione levels rise, they self-limit further GSH synthesis; otherwise, cysteine availability is usually rate-limiting. Fasting, protein-energy malnutrition, or other dietary amino acid deficiencies limit Glutathione synthesis.

Glutathione recycling is catalyzed by Glutathione disulfide reductase, which uses reducing equivalents from NADPH to reconvert GSSG to 2GSH. The reducing power of ascorbate helps conserve systemic Glutathione.

Glutathione is used as a cofactor by (1) multiple peroxidase enzymes, to detoxify peroxides generated from oxygen radical attack on biological molecules; (2) transhydrogenases, to reduce oxidized centers on DNA, proteins, and other biomolecules; and (3) Glutathione S-transferases (GST) to conjugate Gluathione with endogenous substances (e.g., estrogens), exogenous electrophiles (e.g., arene oxides, unsaturated carbonyls, organic halides), and diverse xenobiotics. Low GST activity may increase risk for disease—but paradoxically, some Glutathione conjugates can also be toxic.

Direct attack by free radicals and other oxidative agents can also deplete Glutathione. The homeostatic Glutathione redox cycle attempts to keep Glutathione repleted as it is being consumed. Amounts available from foods are limited (less that 150 mg/day), and oxidative depletion can outpace synthesis.

The liver is the largest Glutathione reservoir. The parenchymal cells synthesize GSH for P450 conjugation and numerous other metabolic requirements—then export GSH as a systemic source of SH-reducing power. Glutathione is carried in the bile to the intestinal luminal compartment. Epithelial tissues of the kidney tubules, intestinal lining and lung have substantial P450 activity—and modest capacity to export Glutathione.

Glutathione equivalents circulate in the blood predominantly as cystine, the oxidized and more stable form of cysteine. Cells import cystine from the blood, reconvert it to cysteine (likely using ascorbate as cofactor), and from it synthesize GSH. Conversely, inside the cell, Glutathione helps re-reduce oxidized forms of other antioxidants—such as ascorbate and alpha-tocopherol.

Mechanism of Action:

Glutathione is an extremely important cell protectant. It directly quenches reactive hydroxyl free radicals, other oxygen-centered free radicals, and radical centers on DNA and other biomolecules. Glutathione is a primary protectant of skin, lens, cornea, and retina against radiation damage and other biochemical foundations of P450 detoxification in the liver, kidneys, lungs, intestinal, epithelia and other organs.

Glutathione is the essential cofactor for many enzymes that require thiol-reducing equivalents, and helps keep redox-sensitive active sites on enzyme in the necessary reduced state. Higher-order thiol cell systems, the metallothioneins, thioredoxins and other redox regulator proteins are ultimately regulated by Glutathione levels—and the GSH/GSSG redox ratio. GSH/GSSG balance is crucial to homeostasis—stabilizing the cellular biomolecular spectrum, and facilitating cellular performance and survival.

Glutathione and its metabolites also interface with energetics and neurotransmitter syntheses through several prominent metabolic pathways. Glutathione availability down-regulates the pro-inflammatory potential of leukotrienes and other eicosanoids. Recently discovered S-nitroso metabolites, generated in vivo from Glutathione and NO (nitric oxide), further diversify Glutathione's impact on metabolism

Glutathione Used in Various Disease States:

Acetaminophen Toxicity, ALS Alzheimer's, ASD (Autism Spectrum Disorder), Cancer, Chronic Fatigue, Cardiovascular Disease, COPD, Lung Disorders, Cystic Fibrosis, Diabetes, Gum Disease, Heavy Metal Toxicity, HIV, Huntington’s Disease, Liver Disease, Lyme Disease, Macular Degeneration, Multiple Sclerosis, Other Neurodegenerative Disease States, Parkinsons Disease, Stroke

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